{"id":9279,"date":"2025-01-26T17:51:48","date_gmt":"2025-01-26T17:51:48","guid":{"rendered":"https:\/\/medicinalherbinfo.org\/000Herbs2016\/?page_id=9279"},"modified":"2025-05-20T15:52:23","modified_gmt":"2025-05-20T15:52:23","slug":"cancer-bush","status":"publish","type":"page","link":"https:\/\/medicinalherbinfo.org\/000Herbs2016\/1herbs\/cancer-bush\/","title":{"rendered":"Cancer Bush"},"content":{"rendered":"<div align=center>\n<h5>Contents:<\/h5>\n<p><a href=\"#Names\">Common Names<\/a> | <a href=\"#Parts\">Parts Usually Used<\/a> | <a href=\"#Description\">Plant(s) &amp; Culture<\/a> | <a href=\"#Where\">Where Found<\/a> | <a href=\"#Properties\">Medicinal Properties<\/a> | <a href=\"#Biochemical\">Biochemical Information<\/a><br \/>\n<a href=\"#Uses\">Uses<\/a> | <a href=\"#Dosages\">Formulas or Dosages<\/a> | <a href=\"#Sold\">How Sold<\/a> | <a href=\"#Warning\">Warning<\/a> | <a href=\"#Links\">Resource Links<\/a><\/p>\n<\/div>\n<h3>Scientific Names<\/h3>\n<p><img decoding=\"async\" src=\"http:\/\/medicinalherbinfo.org\/000Herbs2016\/wp-content\/uploads\/2025\/01\/Sutherlandia_frutescens_PICT3649.jpeg\" alt=\"Cancer bush\" align=\"right\" style=\"width:400px;height:auto\"><\/p>\n<ul>\n<li><em>Sutherlandia frutescens<\/em><\/li>\n<\/ul>\n<h3><a name=\"Names\">Common Names<\/a> <\/h3>\n<p><b><\/p>\n<ul>\n<li>Cancer Bush<\/li>\n<\/ul>\n<p><\/b> <a href=\"#top\"><font size=\"-1\">Back to Top<\/font><\/a> <\/p>\n<hr size=3 width=80% COLOR=\"#004040\" align=\"center\">\n<h3><a name=\"Parts\">Parts Usually Used<\/a><\/h3>\n<p>The leaves, seed pods, and extracts from the plant are used medicinally.<br \/>\n<a href=\"#top\"><font size=\"-1\">Back to Top<\/font><\/a><\/p>\n<hr size=3 width=80% COLOR=\"#004040\" align=\"center\">\n<h3><a name=\"Description\">Description of Plant(s) and Culture<\/a><\/h3>\n<p>A medicinal plant indigenous to South Africa. The plant produces secondary metabolites including sutherlandin flavonoids and triterpenoid compounds, particularly in its leaves and seed pods.<br \/>\n<a href=\"#top\"><font size=\"-1\">Back to Top<\/font><\/a><\/p>\n<hr size=3 width=80% COLOR=\"#004040\" align=\"center\">\n<h3><a name=\"Where\">Where Found<\/a><\/h3>\n<p>Indigenous to and found naturally in South Africa.<br \/>\n            <a href=\"#top\"><font size=\"-1\">Back to Top<\/font><\/a><\/p>\n<hr size=3 width=80% COLOR=\"#004040\" align=\"center\">\n<h3><a name=\"Properties\">Medicinal Properties<\/a><\/h3>\n<p>The plant demonstrates anti-stress, anti-anxiety, anti-inflammatory, anti-cancer, and anti-diabetic properties. It shows particular effectiveness in modulating adrenal hormone biosynthesis and exhibits selective glucocorticoid receptor agonist (SEGRA) and anti-mineralocorticoid properties.<\/p>\n<p>Studies indicate it may be effective in treating chronic diseases including diabetes, obesity, cardiovascular atherosclerosis, arthritis and depression through its effects on the endocrine system.<br \/>\n<a href=\"#top\"><font size=\"-1\">Back to Top<\/font><\/a><\/p>\n<hr size=3 width=80% COLOR=\"#004040\" align=\"center\">\n<h3><a name=\"Biochemical\">Biochemical Information<\/a><\/h3>\n<p>Contains sutherlandin flavonoids and triterpenoid compounds including four complex cycloartane glycosides \u2013 sutherlandiosides (SU) A, B, C and D, with sutherlandioside B (SUB) being the major triterpenoid present. These compounds have molecular structures closely related to steroid hormones.<br \/>\n                  <a href=\"#top\"><font size=\"-1\">Back to Top<\/font><\/a><\/p>\n<hr size=3 width=80% COLOR=\"#004040\" align=\"center\">\n<h3><a name=\"Uses\">Uses<\/a><\/h3>\n<p>Traditional and therapeutic applications include:<\/p>\n<ul>\n<li>Treatment of stress and anxiety<\/li>\n<li>Treatment of inflammation<\/li>\n<li>Cancer therapy<\/li>\n<li>Management of diabetes<\/li>\n<li>Treatment of chronic diseases<\/li>\n<li>Modulation of adrenal hormones<\/li>\n<li>Anti-hypertensive applications<\/li>\n<\/ul>\n<p>\n                <a href=\"#top\"><font size=\"-1\">Back to Top<\/font><\/a><\/p>\n<hr size=3 width=80% COLOR=\"#004040\" align=\"center\">\n<h3><a name=\"Dosages\">Formulas or Dosages<\/a><\/h3>\n<p>In experimental studies, doses of 10 and 30 \u00b5M of sutherlandioside B (SUB) were used to evaluate effects on steroidogenic enzymes and hormone production.<br \/>\n                <a href=\"#top\"><font size=\"-1\">Back to Top<\/font><\/a><\/p>\n<hr size=3 width=80% COLOR=\"#004040\" align=\"center\">\n<h3><a name=\"Sold\">How Sold<\/a><\/h3>\n<p>Available in commercially prepared capsules containing plant extracts.<br \/>\n              <a href=\"#top\"><font size=\"-1\">Back to Top<\/font><\/a><\/p>\n<hr size=3 width=80% COLOR=\"#004040\" align=\"center\">\n<h3><a name=\"Warning\">Warning<\/a><\/h3>\n<p>As the plant affects hormone production and steroid biosynthesis pathways, care should be taken when using alongside other medications that affect these systems. Clinical studies on safety and drug interactions are still limited.<br \/>\n                <a href=\"#top\"><font size=\"-1\">Back to Top<\/font><\/a><\/p>\n<hr size=3 width=80% COLOR=\"#004040\" align=\"center\">\n<h3><a name=\"Links\">Resource Links<\/a><\/h3>\n<p><a href=\"https:\/\/medicinalherbinfo.org\/000Herbs2016\/2025\/01\/28\/african-medicinal-plants-advancing-cancer-treatment-and-management-strategies\/\" target=\"_blank\">African Medicinal Plants Advancing Cancer Treatment and Management Strategies<\/a><\/p>\n<p><a href=\"https:\/\/dmd.aspetjournals.org\/article\/S0090-9556(24)11626-1\/fulltext\" target=\"_blank\">Drug Metabolism and Disposition &#8211; The Potential of Sutherlandia frutescens for Herb-Drug Interaction<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0378874117302192\" target=\"_blank\">ScienceDirect &#8211; Sutherlandia frutescens modulates adrenal hormone biosynthesis, acts as a selective glucocorticoid receptor agonist (SEGRA) and displays anti-mineralocorticoid properties<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23209194\/\" target=\"_blank\">National Library of Medicine &#8211; The potential of Sutherlandia frutescens for herb-drug interaction<\/a><\/p>\n<p><a href=\"https:\/\/en.wikipedia.org\/wiki\/Sutherlandia_frutescens\" target=\"_blank\">Wikipedia &#8211; Sutherlandia frutescens<\/a><\/p>\n<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3924790\/\" target=\"_blank\">National Library of Medicine &#8211; Sutherlandia frutescens: The Meeting of Science and Traditional Knowledge<\/a><\/p>\n<p><a href=\"https:\/\/www.mskcc.org\/cancer-care\/integrative-medicine\/herbs\/sutherlandia-frutescens\" target=\"_blank\">Memorial Sloan Kettering Cancer Center &#8211; Sutherlandia frutescens Purported Benefits, Side Effects &#038; More<\/a><\/p>\n<p>              <a href=\"#top\"><font size=\"-1\">Back to Top<\/font><\/a><\/p>\n<p><center>\t<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-4390707348229770\"\n     crossorigin=\"anonymous\"><\/script><br \/>\n<!-- MHI-wide-728x90 --><br \/>\n<ins class=\"adsbygoogle\"\n     style=\"display:inline-block;width:728px;height:90px\"\n     data-ad-client=\"ca-pub-4390707348229770\"\n     data-ad-slot=\"5012760358\"><\/ins><br \/>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script><\/center><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Contents: Common Names | Parts Usually Used | Plant(s) &amp; Culture | Where Found | Medicinal Properties | Biochemical Information Uses | Formulas or Dosages | How Sold | Warning | Resource Links Scientific Names Sutherlandia frutescens Common Names Cancer Bush Back to Top Parts Usually Used The leaves, seed pods, and extracts from the&#8230;<\/p>\n<p class=\"more-link-wrap\"><a href=\"https:\/\/medicinalherbinfo.org\/000Herbs2016\/1herbs\/cancer-bush\/\" class=\"more-link\">Read More<span class=\"screen-reader-text\"> &ldquo;Cancer Bush&rdquo;<\/span> &raquo;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":2,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"iawp_total_views":110,"footnotes":""},"class_list":["post-9279","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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