Cancer Bush
Parts Usually Used
The leaves, seed pods, and extracts from the plant are used medicinally.
Description of Plant(s) and Culture
A medicinal plant indigenous to South Africa. The plant produces secondary metabolites including sutherlandin flavonoids and triterpenoid compounds, particularly in its leaves and seed pods.
Where Found
Indigenous to and found naturally in South Africa.
Medicinal Properties
The plant demonstrates anti-stress, anti-anxiety, anti-inflammatory, anti-cancer, and anti-diabetic properties. It shows particular effectiveness in modulating adrenal hormone biosynthesis and exhibits selective glucocorticoid receptor agonist (SEGRA) and anti-mineralocorticoid properties. Studies indicate it may be effective in treating chronic diseases including diabetes, obesity, cardiovascular atherosclerosis, arthritis and depression through its effects on the endocrine system.
Biochemical Information
Contains sutherlandin flavonoids and triterpenoid compounds including four complex cycloartane glycosides – sutherlandiosides (SU) A, B, C and D, with sutherlandioside B (SUB) being the major triterpenoid present. These compounds have molecular structures closely related to steroid hormones.
Uses
Historically, herbalists utilized the plant in efforts to address stress and inflammation. Traditional practitioners also incorporated it with the intent of modulating adrenal hormones and supporting blood pressure regulation.
How Sold
Available in commercially prepared capsules containing plant extracts.
Warning
As the plant affects hormone production and steroid biosynthesis pathways, care should be taken when using alongside other medications that affect these systems. Clinical studies on safety and drug interactions are still limited.